The aim is to investigate the genetic relationship between physical activity and bone mineral density.
Conducted a comprehensive genome-wide cross-trait analysis.
Analyzed the shared genetic basis of moderate-to-vigorous physical activity (MVPA) and estimated bone mineral density (eBMD).
Demonstrated a significant relationship between MVPA and eBMD with a genetic correlation of 0.81.
Highlighted MVPA's potential role in osteoporosis prevention through pleiotropic effects on bone density.
Abstract
= 0.81). Our findings demonstrate a shared genetic basis and pleiotropic effects between MVPA and eBMD, highlighting their intrinsic link and supporting MVPA's role in osteoporosis prevention.