Copper-Catalyzed Synthesis of Xanthine–Chalcogenide Hybrids: Structural Diversity, DNA-Interaction Studies, and Docking Simulation

Key Points

• The study aims to synthesize xanthine-chalcogenide hybrids and assess their interactions with DNA.
• Utilized copper-catalyzed C(sp²)-H chalcogenylation for synthesis.
• Employed diaryl dichalcogenides as chalcogen sources.
• Performed docking simulations to study DNA interactions.
• Successfully synthesized a series of xanthine-chalcogenide hybrids under mild conditions.
• Demonstrated significant interaction between the hybrids and DNA.
• Provided structural diversity among synthesized compounds.