RNF145 promotes inflammation in recurrent spontaneous abortion through inducing the K63-linked polyubiquitination of IRF3

Key Points

• This research aims to understand how RNF145 influences inflammation in recurrent spontaneous abortion (RSA) by examining its interaction with IRF3.
• Analyzed levels of IFN-Is and inflammatory cytokines in relation to RNF145 expression in RSA.
• Investigated the interaction between RNF145 and IRF3 in signaling pathways.
• Examined the mechanisms by which RNF145 induces K63-linked ubiquitination of IRF3.
• RNF145 levels are significantly higher in RSA cases, correlating with increased IFN-I and inflammatory cytokine levels.
• RNF145 enhances IRF3-dependent signaling, suggesting a direct role in promoting inflammation.
• K63-linked ubiquitination of IRF3 by RNF145 was confirmed, implicating it in RSA inflammation.