Investigating the genetic basis of fibrotic pathway dysregulation in Dupuytren’s contracture

PURPOSE: Dupuytren's contracture (DC) is a common fibroproliferative disorder with strong genetic predisposition. This study aimed to investigate the association between genetic variants in key fibrotic pathways and DC susceptibility in a Lithuanian population. MATERIALS AND METHODS: rs1668347. RESULTS: = 0.010) models. No significant associations were found for the other investigated SNPs. CONCLUSIONS: rs1668347 provide additional insights into the genetic basis of DC and may contribute to the development of predictive tools and targeted therapies for this debilitating condition.