The high-fat, high-muscle phenotype in adolescents was associated with an increased risk of abnormal blood pressure compared to the low-fat, low-muscle phenotype (OR 3.19; 95% CI 1.77-5.76).
Cross-Sectional (n=1,319)
Are different body composition phenotypes associated with abnormal blood pressure in adolescents?
High fat mass combined with high skeletal muscle mass is associated with a significantly increased risk of abnormal blood pressure in adolescents.
Odds Ratio: 3.19 (95% CI 1.77–5.76)
Objective: To investigate the association between different body composition phenotypes and abnormal blood pressure among adolescents, and to provide a scientific basis for prevention and management strategies targeting abnormal blood pressure in this population. Design and method: Using a stratified cluster sampling method, 1319 adolescents aged 12-18 years from the urban area of Yinchuan City were recruited in 2020 and 2023. Logistic regression models combined with restricted cubic spline analysis were employed to examine the association between adolescent body composition phenotypes and abnormal blood pressure. A bivariate response model was used to analyze the distribution of systolic blood pressure (SBP) and diastolic blood pressure (DBP) across different levels of fat mass index (FMI) and skeletal muscle mass index (SMI). Results: After adjusting for confounding factors, a linear dose-response association was observed between skeletal muscle mass (SMM) and the risk of abnormal blood pressure (Poverall-trend<0.001, Pnon-linear=0.425), while a nonlinear dose-response relationship was found between body fat mass (BFM) and the risk of abnormal blood pressure (Poverall-trend<0.001, Pnon-linear<0.001). The bivariate response model showed that SBP initially increased and then decreased with rising FMI among individuals with low SMI, whereas DBP consistently increased with higher FMI. In the high SMI group, both SBP and DBP increased with increasing FMI. Compared with the low-fat, low-muscle (LFMI-LSMI) phenotype group, the low-fat, high-muscle (LFMI-HSMI) group, the high-fat, low-muscle (HFMI-LSMI) group, and the high-fat, high-muscle (HFMI-HSMI) group all exhibited an increased risk of abnormal blood pressure (ORLFMI-HSMI=2.02, 95%CI: 1.24-3.27; ORHFMI-LSMI=3.14, 95%CI: 1.93-5.10; ORHFMI-HSMI=3.19, 95%CI: 1.77-5.76). Conclusions: The HFMI-HSMI phenotype in adolescents is associated with a significantly increased risk of abnormal blood pressure. Thus, prevention and management of abnormal blood pressure in adolescents should prioritize screening and intervention in this phenotype group.
石龙凯 et al. (Fri,) conducted a cross-sectional in abnormal blood pressure (n=1,319). High-fat, high-muscle (HFMI-HSMI) phenotype vs. Low-fat, low-muscle (LFMI-LSMI) phenotype was evaluated on abnormal blood pressure (OR 3.19, 95% CI 1.77-5.76). The high-fat, high-muscle phenotype in adolescents was associated with an increased risk of abnormal blood pressure compared to the low-fat, low-muscle phenotype (OR 3.19; 95% CI 1.77-5.76).