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June 3, 2026Stem Cell Research & Therapy2 citationsOpen Access

Liver Organoid Models from Induced Pluripotent Stem Cells: Challenges and Strategies

Construction of liver organoid models by hepatobiliary differentiation from human induced pluripotent stem cells: state of the art, challenges and improving strategies

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Authors

YWYihang WuYWYi WangWZWei Zhang

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Overview

Review analyzes challenges and strategies for hepatobiliary differentiation in liver organoids, indicating potential improvements.

Key Points

  • This review aims to evaluate challenges and enhancement strategies for generating liver organoids from induced pluripotent stem cells.
  • Systematic analysis of current hepatobiliary differentiation protocols.
  • Evaluation of physiological relevance and limitations of liver organoid models.
  • Assessment of strategies for improving hepatic maturation and integrating advanced technologies.
  • Identified bottlenecks include incomplete maturation and phenotypic instability of liver organoids.
  • Proposed solutions involve using small molecules and artificial intelligence to improve differentiation protocols.
  • Recommendations for enhancing organoid functionality and standardizing protocols were outlined.

Cite This Study

Wu et al. (2026) studied this question.

synapsesocial.com/papers/6a1fc530dee9eb8c0dce6916https://doi.org/10.1186/s13287-026-05080-8
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