Bone-targeted carbon dots coordinate osteo–angiogenic coupling and antibacterial defense to promote periodontal regeneration

Key Points

• To investigate the effects of bone-targeted carbon dots on osteo–angiogenic coupling and antibacterial defense in periodontal regeneration.
• Evaluated carbon quantum dots with catalase-like and peroxidase-like activities for bone targeting.
• Assessed antibacterial efficiency with membrane depolarization effects and coupled angiogenesis regulation.
• Analyzed the involvement of the Wnt/β-catenin signaling pathway and bone homeostasis.
• Bone-targeting rate was 75.57%.
• Bactericidal efficiency exceeded 95% based on membrane depolarization-induced antibacterial activity.
• Multifunctional carbon dots effectively regulated angiogenesis and the Wnt/β-catenin signaling pathway.