Among asymptomatic young Hispanic adults, metabolic syndrome was significantly associated with increased odds of having an intermediate-high H2FPEF score (OR 2.16).
Cross-Sectional (n=1,285)
No
A significant proportion of asymptomatic young Hispanic adults have intermediate-high H2FPEF scores, driven largely by cardiometabolic risk factors such as metabolic syndrome and elevated HbA1c.
Odds Ratio: 2.16 (95% CI 1.54–3.04)
p-value: p=<0.0001
Heart failure with preserved ejection fraction (HFpEF) prevalence has increased with the increase in cardiometabolic risk factors and yet, diagnosis remains underrecognized in the community, with concomitant undertreatment. H 2 FPEF scoring is a validated tool for dyspnea evaluation but has potential to identify individuals with increased HFpEF risk in asymptomatic populations. Hispanics are known to have high prevalence of cardiometabolic risk, which predispose them to HFpEF. This study aimed to apply the H 2 FPEF score to a community-dwelling Hispanic cohort, and define demographic and clinical covariate associations, particularly in asymptomatic young Hispanic adults. Methods Demographic, cardiometabolic and echocardiographic data were obtained in 1,285 asymptomatic participants (66% females, mean age 53 ± 15 years) from the Cameron County Hispanic Cohort. H 2 FPEF scoring was performed, and the sample divided into low risk (0–2 points) or intermediate-high risk (3–7 points). Analysis was dichotomized to those 60 years and ≥60 years of age, and multivariate logistic regression analyses were conducted. Results Intermediate-high risk H 2 FPEF score was seen in 43% ( n = 555) of the sample. Among those 60 years of age, a third (33%) already had intermediate-high H 2 FPEF scores. After adjusting for covariates, among young Hispanics, age OR=1.02 (1.01–1.04), metabolic syndrome OR=2.16 (1.54–3.04), higher hemoglobin A1c OR 1.23 (1.08–1.39) and sedentary lifestyle OR=0.60 (0.41–0.88) remained significantly associated with odds of increased H 2 FPEF score. Discussion We showed that a large proportion of Hispanics in our cohort have intermediate-high H 2 FPEF scores, and this pattern was already seen among young Hispanics. A simple and useful tool such as the H 2 FPEF score to identify persons at risk for HFpEF, particularly in communities with limited resources, may be relevant for prevention and early intervention, specifically targeting cardiometabolic risk control in young Hispanics.
Kim et al. (Fri,) conducted a cross-sectional in Heart failure with preserved ejection fraction (HFpEF) risk (n=1,285). Metabolic syndrome vs. Absence of metabolic syndrome was evaluated on Intermediate-high H2FPEF score (3-7) in young Hispanics (<60 years) (OR 2.16, 95% CI 1.54-3.04, p=<0.0001). Among asymptomatic young Hispanic adults, metabolic syndrome was significantly associated with increased odds of having an intermediate-high H2FPEF score (OR 2.16).