Dimethyl sulfoxide acutely induces massive, red blood cell-dependent platelet aggregation under arterial shear conditions in a dose-, time-, and shear-dependent manner.
DMSO, a common vehicle solvent, induces massive platelet aggregation in flow assays, highlighting a critical methodological artifact in hemostasis research.
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Dimethyl sulfoxide (DMSO), widely used as vehicle solvent in hemostasis research, acutely induces massive platelet aggregation under arterial shear conditions in a dose-, time-, and shear-dependent manner. This red blood cell-dependent prothrombotic effect warrants immediate caution when interpreting microfluidic and flow-based thrombosis assays.
Ramasundara et al. (Mon,) reported a other. Dimethyl sulfoxide acutely induces massive, red blood cell-dependent platelet aggregation under arterial shear conditions in a dose-, time-, and shear-dependent manner.