Copper-Mediated Trimerization of Diazopeptides Generates Peptide Derivatives of Cis - and Trans -Aconitic Acid That Adopt Folded Structures

Key Points

• This research aims to explore how copper-mediated trimerization of diazopeptides produces derivatives of aconitic acid with distinct structures.
• Utilized computational analyses and NMR methods to evaluate peptide derivatives.
• Investigated the conformation of cis- and trans-aconitic acid isomers formed from diazopeptide trimerization.
• Both isomers of aconitic acid exhibit a conformation with two intramolecular hydrogen bonds.
• Structural analysis reveals parallel and perpendicular orientations of the peptide chains involved.