What is the clinical evidence from this study?

Study design: Case-Control. Population: Coronary heart disease (n=380). Intervention: circ_0092576 vs. Non-CHD controls / Low circ_0092576 levels. Primary outcome: Coronary heart disease prediction (AUC 0.885).

What does this research mean for the field?

Elevated plasma levels of circ_0092576 serve as a biomarker for coronary heart disease, correlating with increased disease risk, greater arterial stenosis severity, heightened inflammatory status, and a higher incidence of major adverse cardiac events. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This study aims to explore the predictive value of circ_0092576 in coronary heart disease and its relationship with arterial stenosis severity and inflammatory status.

June 4, 2026Open Access

Correlation Between circ₀092576 and Arterial Stenosis Severity and Inflammatory Status in Patients with Coronary Heart Disease and Its Clinical Value

Key Result

Elevated plasma circ_0092576 levels strongly predicted coronary heart disease (AUC 0.885) and were associated with more severe stenosis, stronger inflammation, and increased risk of MACE.

Key Points

This study aims to explore the predictive value of circ_0092576 in coronary heart disease and its relationship with arterial stenosis severity and inflammatory status.
Measured plasma levels of circ_0092576, IL-1β, TNF-α, and IL-10 using RT-qPCR in 200 CHD patients and 180 controls.
Assessed coronary artery stenosis severity using the Gensini score system and monitored MACE occurrence during follow-up.
Conducted statistical analysis including ROC curve calculations to determine predictive performance of circ_0092576.
Circ_0092576 levels were significantly higher in CHD patients (AUC = 0.885).
Positive correlations were found between circ_0092576, Gensini scores, IL-1β, and TNF-α; a negative correlation was noted with IL-10.
High circ_0092576 group showed a significantly higher cumulative incidence of MACE compared to the low circ_0092576 group.

Study Design

Type

Case-Control (n=380)

Structured PICO

Does circ_0092576 level predict CHD risk, MACE, and correlate with coronary stenosis severity and inflammation?

Population

380 participants comprising 200 patients with coronary heart disease and 180 non-CHD controls, followed for major adverse cardiac events.

Exposure

Plasma levels of circ_0092576

Comparator

Non-CHD controls (for diagnosis) and low circ_0092576 group (for prognosis)

Outcome

Predictive value for CHD and major adverse cardiac events (MACE) risksurrogate

Elevated plasma circ_0092576 serves as a potential biomarker for diagnosing CHD, assessing coronary stenosis severity, and predicting MACE.

Main Result

Effect estimate: AUC 0.885

Abstract

This study aims to investigate the predictive value of circ₀092576 for coronary heart disease (CHD) and major adverse cardiac events (MACE) risk, and to elucidate its association with the degree of coronary artery stenosis and inflammatory status. A total of 200 CHD patients and 180 non-CHD controls were recruited. Plasma levels of circ₀092576, IL-1β, TNF-α and IL-10 were measured using RT-qPCR. Coronary artery stenosis severity was assessed using the Gensini score system, and MACE occurrence was recorded during regular follow-up. circ₀092576 levels were significantly higher in CHD patients than in the control group, with an area under the ROC curve (AUC) of 0. 885. Furthermore, circ₀092576 showed significant positive correlations with Gensini scores and pro-inflammatory factors IL-1β and TNF-α while exhibiting a negative correlation with the anti-inflammatory factor IL-10. Follow-up revealed significantly elevated circ₀092576 levels in patients who developed MACE. Compared to the low circ₀092576 group, the high circ₀092576 group exhibited a significantly higher cumulative incidence of MACE. Elevated circ₀092576 levels correlate with increased risk of CHD and subsequent MACE. In summary, circ₀092576 is a potential biomarker for CHD risk and prognosis. Elevated levels indicate increased risk of CHD, more severe coronary artery stenosis, stronger inflammation, and are associated with an increased risk of adverse cardiac events.

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