Randomized trial shows enhanced adhesion of MSCs in cartilage, suggesting PRP aids repair strategies.
Key Points
The aim was to evaluate the effect of platelet-rich plasma (PRP) on the adhesion and retention of bone marrow-derived mesenchymal stromal cells (BM-MSCs) at cartilage sites.
BM-MSCs and chondrocytes were treated with PRP for different durations (10 or 30 min) and adhesion assessed using a viability assay.
Ex vivo tests evaluated MSC adhesion on osteochondral discs with varying lesion severity by fluorescence imaging.
PRP significantly improved BM-MSC and chondrocyte adhesion, notably with 30 min pretreatment, p < 0.001.
Adhesion increased with lesion severity (G1 to G3), with significant retention in G2 and G3 lesions, p < 0.05 and p < 0.01 respectively.
PRP pretreatment 30 min boosted BM-MSCs adhesion compared to controls, both p < 0.01.