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June 4, 2026Nature Communications0 citationsOpen Access

Adipocyte Differentiation in Visceral Adipose Tissue Affects Liver Disease

Decreased degree of adipocyte differentiation in visceral adipose tissue contributes to metabolic dysfunction-associated steatotic liver disease

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Authors

KGKyla GelevSLSeung Hyuk LeeMAMarcus Alvarez

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Overview

Randomized trial reveals decreased adipocyte differentiation in visceral fat contributes to metabolic dysfunction-associated liver disease.

Key Points

  • This research aims to explore the link between adipocyte differentiation in visceral adipose tissue and metabolic dysfunction-associated steatotic liver disease (MASLD).
  • Single nucleus RNA-sequencing used on adipose tissue biopsies to assess adipocyte differentiation.
  • Comparison of gene expression in visceral adipose tissue and subcutaneous adipose tissue among individuals with MASLD and obesity.
  • Heritability analysis of VAT adipocyte differentiation gene sets in relation to MASLD.
  • Predicted VAT adipocyte differentiation is significantly decreased in individuals with MASLD.
  • The differentiation gene set accounts for 17% of MASLD heritability, overlapping with differentially expressed adipocyte genes.
  • Associated adipocyte genes correlate with smaller adipocyte sizes.

Cite This Study

Gelev et al. (2026) studied this question.

synapsesocial.com/papers/6a211611d499ed480b16f0fdhttps://doi.org/10.1038/s41467-026-73660-6
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