Unlocking the antidiabetic potential of novel pyrazole-triazole hybrids through synthesis, dual α-amylase/α-glucosidase inhibition, multiscale biological evaluation, and molecular dynamics studies

Key Points

• The research focuses on developing effective antidiabetic agents using a new pyrazole-based scaffold.
• Designed novel pyrazole-linked carbohydrazide compounds.
• Evaluated dual inhibition of α-amylase and α-glucosidase activities.
• Conducted multiscale biological evaluations and molecular dynamics studies.
• Identified strong inhibition of α-amylase and α-glucosidase activities by the novel compounds.
• Demonstrated enhanced potential for these agents in managing diabetes through structural evaluations.
• Molecular dynamics indicated favorable interactions with target enzymes.