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June 4, 2026Journal of Medicinal Chemistry0 citations

Cationic Photosensitizer-Functionalized Bacteria for Targeted Photothermal-Photodynamic Therapy with Immune Activation

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LLLing LeiJLJunyi LiuYLYang Liu

Key Points

  • The research investigates how cationic photosensitizer-functionalized bacteria can improve cancer treatment by promoting immune responses and tumor targeting.
  • Cationic photosensitizer-functionalized bacteria were utilized as carriers for targeted therapy.
  • The effects on immunogenic cell death, dendritic-cell maturation, and T-cell activation were measured.
  • In vivo experiments demonstrated the therapy's efficacy in solid tumor regression.
  • Achieved 94.4% inhibition of solid tumors in vivo.
  • Enhanced immune activation was observed, including dendritic-cell maturation and T-cell activation.
  • Improved targeting of tumors with functionalized bacteria was confirmed.

Abstract

induces immunogenic cell death, promotes dendritic-cell maturation, and amplifies T-cell activation, ultimately leading to substantial solid tumor regression (94.4% inhibition in vivo). This work demonstrates that cationic photosensitizer-functionalized bacteria can enhance bacterial tumor targeting and photoimmune therapeutic efficacy, providing a chemically guided strategy for bacteria-based cancer treatment.

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Cite This Study

Lei et al. (2026) studied this question.

synapsesocial.com/papers/6a211689d499ed480b16f799https://doi.org/10.1021/acs.jmedchem.6c00640
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