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June 4, 2026International Journal of Molecular Sciences0 citationsOpen Access

TiO2 Nanoparticles Induce Gut-to-Gill Bacterial Translocation and Dysbiosis in Zebrafish

TiO2 Nanoparticles Trigger Gut-to-Gill Bacterial Translocation and Dysbiosis in Zebrafish

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Authors

CLChi‐Cheng LiDSDer‐Shan SunTLTe-Sheng Lien

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Overview

Randomized trial investigates TiO2-NP exposure effects on gut dysbiosis in zebrafish, suggesting new ecological risks.

Key Points

  • This study aims to understand how titanium dioxide nanoparticles affect microbial interactions and gut health in zebrafish.
  • Utilized zebrafish as a sentinel species to assess the effects of 5 mg/L TiO2-NP exposure over a subchronic duration.
  • Employed dynamic light scattering for nanoparticle characterization and performed 16S rRNA metagenomic profiling.
  • Analyzed microbial changes in the gut and gills to establish gut-to-gill translocation pathways.
  • Observed a 333-fold reduction in beneficial Cetobacterium and an 856-fold increase in pathogenic Mycobacterium.
  • Chao1 richness increased significantly (p < 0.01), indicating gut dysbiosis.
  • Gut and gill microbial profiles showed convergence, supporting the gut-to-gill translocation hypothesis.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6a211743d499ed480b1701efhttps://doi.org/10.3390/ijms27115036
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