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June 4, 2026Clinical and Experimental OtorhinolaryngologyOpen Access

Prognostic Significance of Microscopic Positive Margin in Differentiated Thyroid Carcinoma: A Systematic Review and Meta-Analysis

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Authors

JAJeongshin AnHHHyeonuk HwangHKHyeji Kim

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Overview

Systematic review demonstrates association between microscopic positive margins and recurrence in thyroid cancer, suggesting evaluation of margin location is critical.

Key Points

  • The study aims to clarify the relationship between microscopic positive surgical margins (mPSM) and cancer recurrence in differentiated thyroid carcinoma.
  • Systematic review and meta-analysis conducted using multiple databases including Cochrane, MEDLINE, and EMBASE.
  • Independent extraction of study characteristics and hazard ratios from included studies by three reviewers.
  • Subgroup analysis performed based on margin location.
  • Patients with mPSM had a higher recurrence rate (pooled HR 1.78, 95% CI 1.43-2.20) compared to those with clear margins.
  • In papillary thyroid carcinoma specifically, recurrence rates were also significantly higher (pooled HR 1.87, 95% CI 1.34-2.60).
  • Subgroup analysis indicated a markedly increased risk with posterior mPSM (pooled HR 5.23, 95% CI 1.41-19.46); anterior mPSM showed a nonsignificant association (pooled HR 1.22, 95% CI 0.82-1.82; P = 0.32).

Cite This Study

An et al. (2026) studied this question.

synapsesocial.com/papers/6a211763d499ed480b17040dhttps://doi.org/10.21053/ceo.2026-00028
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Context-Dependent Prognostic Impact of Microscopic Positive Surgical Margin in Papillary Thyroid Carcinoma2026
  2. 2Prognostic Factors and Recurrence in Papillary Thyroid Microcarcinoma2026
  3. 3Positive surgical margins and biochemical recurrence following minimally-invasive radical prostatectomy – An analysis of outcomes from a UK tertiary referral centre2017 · 39 citations
  4. 4Does Margin Length Predict Recurrence After Partial Nephrectomy, or Is Presence Alone Sufficient?2026
  5. 5Analysis of Risk Factors for High-Risk Lymph Node Metastasis in Papillary Thyroid Microcarcinoma2025 · 1 citations