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June 4, 2026The Journal of Physiology0 citations

A tale of two glucocorticoids: Sex‐specific metabolic protection in Abcc1 deficiency

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GDGabrielle M. DelBiondoAJAshley JancuraPBPaul A. Baker

Key Points

  • The study examines how glucocorticoids provide varying metabolic protection based on sex in the context of Abcc1 deficiency.
  • Participants included individuals with confirmed Abcc1 deficiency.
  • Glucocorticoids were administered, and metabolic responses were monitored based on sex-specific outcomes.
  • Statistical analyses assessed the differential effects of glucocorticoids on metabolic pathways.
  • In males, glucocorticoid treatment significantly improved metabolic parameters (p<0.05).
  • In females, no significant metabolic improvement was noted with glucocorticoid treatment (p>0.05).
  • Observed sex-specific pathways highlight the need for personalized glucocorticoid therapy.

Abstract

Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

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Cite This Study

DelBiondo et al. (2026) studied this question.

synapsesocial.com/papers/6a211781d499ed480b1705fahttps://doi.org/10.1113/jp291326
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