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June 4, 2026International Journal of Molecular SciencesOpen Access

Highly Aggressive and Metastatic MDA-MB-231 and Mel Z Cancer Cells Have Common Sets of Down- and Upregulated Genes During Formation of the Vasculogenic Mimicry Phenotype

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Authors

NTNickolai A. TchurikovEKElena S. KlushevskayaVLViktoriya N. Lukicheva

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Overview

Randomized trial reveals gene expression changes during vasculogenic mimicry in cancer cells, suggesting new therapy targets.

Key Points

  • This research aims to understand the gene expression changes in MDA-MB-231 and Mel Z cancer cells during vasculogenic mimicry.
  • Compared transcriptomes of MDA-MB-231 and Mel Z cancer cells.
  • Identified up- and downregulated genes associated with vasculogenic mimicry.
  • Knocked down the SERPINE1 gene to assess its role in VM development.
  • Identified 51 upregulated and 98 downregulated genes common to both cell lines.
  • Upregulated genes include nine involved in blood vessel development and tube morphogenesis.
  • SERPINE1 knockdown prevents VM formation in Mel Z cells.

Cite This Study

Tchurikov et al. (2026) studied this question.

synapsesocial.com/papers/6a211852d499ed480b170f75https://doi.org/10.3390/ijms27114952
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