Lower nailfold capillary density and greater capillary disorganization were significantly associated with the presence of cardiac arrhythmias and conduction blocks in patients with systemic sclerosis.
Cross-Sectional (n=110)
Single-blind
No
Are nailfold capillaroscopic features associated with cardiac block and arrhythmias in patients with systemic sclerosis?
Lower capillary density and greater disorganization on nailfold capillaroscopy are associated with arrhythmias and conduction blocks in systemic sclerosis patients with primary heart involvement.
Absolute Event Rate: 2.19% vs 1.72%
p-value: p=0.04
Objectives Impaired microvascular function has been implicated as a complication affecting multiple organs in systemic sclerosis (SSc). We investigated the correlation between microvascular damage on nailfold video capillaroscopy (NVC) and cardiac arrhythmias or conduction blocks in patients with primary heart involvement (pHI). Material and methods One hundred ten patients with SSc underwent an NVC study. Thirty-one patients with arrhythmias or conduction blocks were included in the study group. No patients in this group had pulmonary arterial hypertension, systemic hypertension, or ischemic heart disease. Seventy-nine patients with no arrhythmia or block were included in the control group. Qualitative, quantitative, and semi-quantitative capillaroscopic parameters were compared between the 2 groups. Results In the qualitative NVC analysis the odds ratio (OR) for the early pattern in groups of patients with and without a cardiac outcome was 0.93 (95% CI: 0.35–2.45; p = 0.89). The ORs for the active and late patterns in the 2 groups of patients were 0.92 (95% CI: 0.37–2.30, p = 0.86) and 1.07 (95% CI: 0.52–2.19; p = 0.84), respectively. Semi-quantitative assessment in 6 NVC parameters showed that the mean score for capillary density was higher in the outcome group than in the non-outcome group (mean ±standard deviation: 2.19 ±0.910 vs. 1.72 ±1.120; p = 0.04). Capillary disorganization also showed a higher score in patients with cardiac involvement than in those without (1.00 ±0.01 vs. 0.95 ±0.221, p = 0.001). Low capillary density in NVC was associated with sensitivity (Se) of 96.7%, and specificity (Sp) of 18.9%. Disorganized capillaries showed Se of 96.7% and Sp of 5%. However, no significant differences were observed in enlarged capillaries, giant capillaries, microhemorrhages, or ramifications. Conclusions Lower capillary density and greater disorganization are associated with arrhythmias and conduction blocks in SSc-PHI. The quantitative capillaroscopic parameters were comparable between patients with arrhythmias due to SSc-PHI and those in the non-outcome group. A detailed semi-quantitative capillaroscopic assessment is recommended in scleroderma patients.
Salimi-Beni et al. (Fri,) conducted a cross-sectional in Systemic sclerosis (n=110). Nailfold capillaroscopic abnormalities (low capillary density and disorganization) vs. Normal capillaroscopic features was evaluated on Capillary density score (p=0.04). Lower nailfold capillary density and greater capillary disorganization were significantly associated with the presence of cardiac arrhythmias and conduction blocks in patients with systemic sclerosis.