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Challenges in healthcare facilities, especially emergency departments (EDs), persistently arise from increasing patient volumes, pandemics, and complex operational factors. This study explores the use of graph-theoretic methods as powerful tools for optimizing hospital layouts. Initially, we introduced a multi-objective optimization framework informed by graphs for the design of ED layouts, utilizing NSGA-II and GDE3, with the objectives of minimizing patient flow costs and enhancing the spatial proximity of service areas. We propose and confirm the application of both local and global graph-theoretic metrics, including centrality metrics, clustering coefficients, and network efficiency, to assess and rank Pareto-optimal layouts. Simulation results on the layout of an ED in Dalian, China, show that the best-ranked layouts exhibit superior graph-theoretic values, with the NSGA-II and GDE3 solutions reducing patient flow cost by 18.32% and 11.42%, respectively, and improving service area closeness by 14.5% and 18.02%, respectively. Subsequently, we present a layout prediction method based on machine learning that employs multi-output regression models trained on graph-theoretic features extracted from a large set of optimization-based layout solutions. The proposed models, particularly decision trees and random forests, demonstrated impressive prediction accuracies of up to 98.18% and 88.06%, respectively, showcasing their effectiveness in efficiently producing optimal layouts. Collectively, these findings highlight the potential of graph-theoretic models in enhancing hospital design and operational decision-making.
Sarhan et al. (2026) studied this question.