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June 5, 2026PharmaceuticalsOpen Access

Phytochemical Characterization and the First Report on the Antiproliferative Activity and Cytotoxicity of Thymus fedtschenkoi var. handelii (Ronniger) Jalas

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TKTünay KaranAAALİ AYDINÇSÇağrı Çağlar Sinmez

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Overview

Randomized trial shows strong antiproliferative activity in cancer cell lines, suggesting therapeutic potential.

Key Points

  • This research investigates the phytochemical makeup of Thymus fedtschenkoi var. handelii and evaluates its anticancer activity.
  • Plant collection from natural habitat for essential oil composition analysis using GC-MS
  • Evaluation of anticancer efficacy and cytotoxicity using MTT and lactate dehydrogenase methods
  • Testing against various cancer and normal cell lines
  • Essential oils contained 51.12% carvacrol, 16.87% γ-gamma-terpinene, and 14.76% p-cymene
  • Both extracts (GI50: 1.10–3.28 µg/mL) and essential oils (GI50: 1.05–2.03 µg/mL) exhibited strong antiproliferative activity
  • Essential oils demonstrated superior growth suppression (TGI: 1.97–9.19 µg/mL), while extracts required higher concentrations for similar effects

Cite This Study

Karan et al. (2026) studied this question.

synapsesocial.com/papers/6a2267f6763171746d546830https://doi.org/10.3390/ph19060844
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