Elevated ApoB levels (OR 15.311), standard deviation of blood glucose (OR 1.409), and low blood glucose index (OR 1.327) were independently associated with comorbid major depressive disorder in older adults with type 2 diabetes.
Observational (n=145)
Are lipid profiles and glucose fluctuations associated with clinically diagnosed depression in older adults with type 2 diabetes?
Abnormal lipid levels (specifically ApoB) and glucose fluctuations (SDBG, LBGI) are independently associated with major depressive disorder in hospitalized older adults with type 2 diabetes.
Odds Ratio: 15.311 (95% CI 2.688–87.205)
p-value: p=0.002
Introduction Major depressive disorder (MDD) frequently occurs in elderly patients with type 2 diabetes (T2D), amplifying the overall disease burden. While lipid and glucose fluctuations have been suggested as contributors to MDD, their precise roles in clinically diagnosed secondary depression require further elucidation. This study aimed to identify key indicators related to lipids and glycemic levels associated with depression in older adults with type 2 diabetes. Methods We retrospectively analyzed data from 145 hospitalized T2D patients aged 60 years or older, including 86 with MDD and 59 without MDD. We gathered information on their lipid profiles (e.g., total cholesterol TC, apolipoprotein B ApoB) and glucose fluctuations (e.g., standard deviation of blood glucose SDBG, low blood glucose index LBGI, time in range TIR) using continuous glucose monitoring (CGM). Univariate and multivariate logistic regression analyses were conducted to identify factors independently associated with clinically diagnosed depression. Results The prevalence of comorbid MDD among hospitalized older adults with T2D was 59.31% (86/145). Correlation analysis demonstrated significant associations between glycemic variability, lipid parameters, and psychological measures. In multivariable logistic regression, ApoB (OR = 15.311, 95% CI 2.688, 1on,le p = 0.002), SDBG (OR = 1.409, 95% CI 1.121= 1on,l p = 0.003), and LBGI (OR = 1.327, 95% CI 1.101= 1on,l p = 0.003) remained independently associated with comorbid MDD. Conclusion In this study, the prevalence of comorbid MDD among hospitalized older T2D patients was 59.31% (86/145). Abnormal lipid levels and glucose fluctuations are strongly associated with MDD in older T2D patients. ApoB, SDBG, and LBGI may serve as potential clinical markers associated with comorbid MDD. Further larger prospective studies are necessary to confirm these findings and inform clinical management.
Geng et al. (Tue,) conducted a observational in Type 2 Diabetes and Major Depressive Disorder (n=145). Elevated Apolipoprotein B (ApoB) and glycemic variability vs. Lower levels of ApoB and glycemic variability was evaluated on Clinically diagnosed comorbid Major Depressive Disorder (MDD) (OR 15.311, 95% CI 2.688-87.205, p=0.002). Elevated ApoB levels (OR 15.311), standard deviation of blood glucose (OR 1.409), and low blood glucose index (OR 1.327) were independently associated with comorbid major depressive disorder in older adults with type 2 diabetes.