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September 2, 2024Rheumatology Science and PracticeOpen Access

IL-17A, IL-17F and IL-23 in patients with rheumatoid arthritis

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Authors

NLN. A. LapkinaАБА. А. БарановORO. P. Rechkina

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Overview

Observational analysis reveals elevated serum IL-23 and frequent IL-17F hyperproduction in advanced rheumatoid arthritis, suggesting cytokine elevation does not amplify overall disease activity.

Key Points

  • Serum IL-23 levels were significantly elevated in advanced rheumatoid arthritis, whereas IL-17A and IL-17F concentrations did not differ significantly from healthy donor controls.
  • Elevated IL-17F occurred in 46.1% of patients, whereas IL-23 hyperproduction was detected in 42.9% of individuals with advanced rheumatoid arthritis.
  • Analysis using multiplex xMAR technology indicates that combined elevation of IL-17A, IL-17F, and IL-23 does not augment individual proinflammatory activity in rheumatoid arthritis.

Cite This Study

Lapkina et al. (2024) studied this question.

synapsesocial.com/papers/68e59a2bb6db643587534ee6https://doi.org/10.47360/1995-4484-2024-402-407
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