Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
March 26, 2026Advanced ScienceOpen Access

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

View Full Paper
Ask AI
Bookmark
Share

Authors

MSMinji SeoJLJangsoon LeeNUNaoto T. Ueno

Discussion

Loading...

Member takes

Overview

Analytical frameworks uncover ADC resistance mechanisms in breast cancer, suggesting new treatment strategies.

Key Points

  • This research aims to explore the mechanisms behind resistance to antibody-drug conjugates in breast cancer and identify potential solutions.
  • Analyzing interactions between cancer cells and the tumor microenvironment
  • Employing technologies like spatial omics and single-cell profiling
  • Studying clonal evolution and pathway reprogramming in ADC resistance
  • Identified multiple factors contributing to ADC resistance, including stromal architecture and immune modulation
  • Proposed new therapeutic strategies like next-generation ADC designs and co-targeting pathways
  • Outlined how integrating biological and technological insights can improve treatment durability

Cite This Study

Seo et al. (2026) studied this question.

synapsesocial.com/papers/69c4cddcfdc3bde44891ab2dhttps://doi.org/10.1002/advs.202515498
View Full Paper
Ask AI
Bookmark
Share