The INOCA-IT Registry evaluates tailored therapy impacts on angina and quality of life in patients with INOCA in Italy, indicating significant improvements.
Key Points
This research aims to explore gender and geographical differences in INOCA and its endotypes while evaluating the effect of tailored therapies on symptoms and quality of life.
Prospective enrollment of patients with angina and inducible ischemia in three Italian centers.
Assessment of coronary flow reserve, index of microvascular resistance, and acetylcholine provocative testing.
Stratification of patients into endotypes: coronary microvascular dysfunction, vasospastic angina, microvascular spasm, and chest pain of non-cardiac origin.
Follow-up evaluation via Seattle Angina Questionnaire and EQ-5D-5L at one year.
213 patients enrolled with a median age of 61 years, 60.1% female.
Coronary microvascular dysfunction was the most common endotype at 22.5%.
Improvement in CCS angina class and median SAQ summary score from 57.5 to 81.8 at one year (p<0.001).
Significant enhancements in each EQ-5D-5L domain and an increase in EQ VAS from 70 to 80 (p<0.001).
Women reported worse angina severity and QOL at baseline and follow-up despite similar therapy.