What question did this study set out to answer?

To evaluate the role of PRAME in immunohistochemical differentiation of atypical fibroxanthoma from malignant melanoma and histological mimics.

April 10, 2026

Comprehensive Immunohistochemical Analysis of Atypical Fibroxanthoma: Focus on PRAME in Differential Diagnosis

Key Points

To evaluate the role of PRAME in immunohistochemical differentiation of atypical fibroxanthoma from malignant melanoma and histological mimics.
Conducted immunohistochemical analysis on AFX samples
Assessed expression of PRAME and CD10
Compared findings with other histological diagnoses
PRAME expression was absent in AFX samples
Block-type CD10 positivity noted in AFX
Differentiation from malignant melanoma enhanced using these markers

Abstract

A comprehensive immunohistochemical panel is essential for the accurate diagnosis of AFX. The absence of PRAME expression, together with block-type CD10 positivity, supports the distinction of AFX from malignant melanoma and other histological mimics, facilitating appropriate clinical management.

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Cite this study

Sahin et al. (Tue,) studied this question.

www.synapsesocial.com/papers/69d893406c1944d70ce044d2 — DOI: https://doi.org/10.1097/dad.0000000000003276

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Authors

Gozde Gungor Sahin

Elif Eroğlu

Nesimi Bűyúkbabani

Journals

American Journal of Dermatopathology

Actions

Institutions

Istanbul University

Koç University

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Comprehensive Immunohistochemical Analysis of Atypical Fibroxanthoma: Focus on PRAME in Differential Diagnosis

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Cite this study

Also consider

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion