Comprehensive Immunohistochemical Analysis of Atypical Fibroxanthoma: Focus on PRAME in Differential Diagnosis

Key Points

• To evaluate the role of PRAME in immunohistochemical differentiation of atypical fibroxanthoma from malignant melanoma and histological mimics.
• Conducted immunohistochemical analysis on AFX samples
• Assessed expression of PRAME and CD10
• Compared findings with other histological diagnoses
• PRAME expression was absent in AFX samples
• Block-type CD10 positivity noted in AFX
• Differentiation from malignant melanoma enhanced using these markers

Abstract