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April 13, 2026ANZ Journal of Surgery

Seven Years of Watch and Wait With Rectal Cancer—Reflections and Optimisations

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Authors

BFBen FinlayEPEmma PowellALA. Long

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Overview

Observations track regrowth in rectal cancer patients, suggesting improvements in treatment protocols.

Key Points

  • Evaluate the effectiveness and outcomes of the watch and wait strategy for rectal cancer after LCCRT.
  • Assessment of clinical and pathological responses in patients after lateral chemoradiation therapy (LCCRT) at SCGH.
  • Monitoring surveillance protocol for early detection of local regrowth.
  • Analysis of surgical outcomes related to complete clinical response (cCR) and pathological complete response (pCR).
  • 24% of patients achieved complete clinical response (cCR) after treatment, with 84% sustaining this response.
  • 16% of watch and wait patients showed signs of local regrowth during surveillance.
  • 20% of patients experienced pathological complete response (pCR) during surgery despite not achieving cCR.

Cite This Study

Finlay et al. (2026) studied this question.

synapsesocial.com/papers/69dc88f43afacbeac03eaa95https://doi.org/10.1111/ans.70672
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Long term outcome of patients with rectal cancer with complete clinical response or near complete clinical response after neoadjuvant therapy: A multicenter registry study by Chinese Watch and Wait Database.2024
  2. 2Potential Cure of Rectal Cancer after Neoadjuvant Concurrent Chemoradiotherapy with Clinical Complete Response after Local Treatment2026
  3. 3FP2.1 - The accuracy of radiological staging in rectal cancer patients post-long course chemoradiotherapy treatment2024
  4. 4Non-operative management of locally advanced rectal cancer with an emphasis on outcomes and quality of life: a narrative review2025 · 2 citations
  5. 5Organ preservation in rectal cancer following clinical complete response after short-course radiotherapy-based total neoadjuvant therapy2026