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April 17, 2026Fish Physiology and BiochemistryOpen Access

Evaluation of sample preparation methods for NMR-based metabolomics of Atlantic salmon (Salmo salar) ovarian fluid

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Authors

FCFabio CasuABAmanda L. BaylessBPBrian C. Peterson

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Overview

The evaluation of sample preparation methods improves metabolite analysis in Atlantic salmon, suggesting actionable insights for aquaculture.

Key Points

  • This study aims to evaluate various sample preparation methods for NMR-based metabolomics of ovarian fluid to improve insights into reproductive success.
  • Tested seven sample preparation methods for NMR metabolomics analysis of ovarian fluid.
  • Methods included filtration, protein precipitation, lyophilization, dilution, and combinations.
  • Assessed the quality of metabolite spectra and the effects of blood contamination.
  • Filtration-concentration method yielded the highest quality spectra, with lower variability.
  • The method demonstrated a better signal-to-noise ratio compared to others.
  • Blood contamination during collection significantly affected metabolite profiles.

Cite This Study

Casu et al. (2026) studied this question.

synapsesocial.com/papers/69e1cf7b5cdc762e9d8586b2https://doi.org/10.1007/s10695-026-01678-0
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