This observational study evaluates serum interleukin-10 as a biomarker for deep remission in ulcerative colitis, suggesting its potential clinical relevance.
Key Points
The study aims to evaluate the association of serum interleukin-10 levels with deep remission in ulcerative colitis and its diagnostic performance.
Conducted a prospective observational study at a single center
Measured serum IL-10 concentrations in patients prior to colonoscopy
Defined histologic healing using a Geboes score below 2.0
Applied Firth penalized logistic regression for association analysis
Assessed discrimination using receiver operating characteristic analysis with bootstrap validation.
40.9% of patients achieved deep remission
Serum IL-10 levels were significantly higher in patients with histologic healing (p < 0.001)
Log-transformed IL-10 was independently associated with deep remission
The multivariable model showed good discrimination (AUC 0.88)
Non-detectable IL-10 indicated persistent histologic activity with high sensitivity (92.9%) and negative predictive value (94.4%).