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May 6, 2026RSC AdvancesOpen Access

Studies on the Lewis acid catalyzed synthesis of isoxazolidin-3-ones

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Authors

YXYining XuanLYLianbao YeLJLilan Jin

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Overview

Randomized trial explores synthesis of isoxazolidin-3-ones in various conditions, suggesting improved substrate compatibility.

Key Points

  • To investigate a Lewis acid catalyzed method for synthesizing isoxazolidin-3-ones using a sustained-release substrate strategy.
  • Employing Lewis acid catalysts to facilitate the reaction under mild conditions.
  • Implementing a sustained-release strategy to prevent catalyst poisoning during the synthesis process.
  • Utilizing chiral epoxy substrates to assess enantiomeric purity of the products.
  • Synthesis of a wide array of substituted isoxazolidin-3-ones was achieved efficiently.
  • Utilization of inexpensive starting materials made the process cost-effective.
  • High retention of enantiomeric purity was obtained when chiral substrates were used.

Cite This Study

Xuan et al. (2026) studied this question.

synapsesocial.com/papers/69fada7f03f892aec9b1e44chttps://doi.org/10.1039/d6ra02399a
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