Randomized trial demonstrates enhanced collagen production in scleral fibroblasts, suggesting a strategy for myopia intervention.
Key Points
The primary aim is to investigate the effect of magnetic stimulation on scleral fibroblast proliferation and collagen synthesis using MNP/G nanocomposites.
Synthesized magnetic/graphene composites via covalent co-precipitation.
Co-cultured human scleral fibroblasts with 30 μg/mL MNP/G while applying static magnetic stimulation at 20 mT.
Assessed cell proliferation through CCK-8 assay and quantified collagen synthesis via hydroxyproline content measurement.
Magnetic stimulation significantly increased HFSF proliferation compared to controls, with improved cell morphology.
Measured collagen synthesis was markedly higher following magnetic stimulation and the combined application of MNP/G nanomaterials.
This strategy shows potential for strengthening scleral biomechanical properties and counteracting myopia progression.