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May 6, 2026Chemical ScienceOpen Access

A reflection on synthesis by extrusion ten years on: achievements, challenges and opportunities for solvent-free, sustainable, continuous chemical manufacturing

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Authors

DCDeborah E. CrawfordSJStuart L. James

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Overview

Reflection discusses achievements and challenges in solvent-free continuous chemical manufacturing, indicating future potential.

Key Points

  • The aim is to reflect on the advancements and challenges in mechanochemical synthesis over the past decade.
  • Review of the literature on mechanochemical synthesis and its applications.
  • Analysis of the development and implementation of solvent-free techniques in manufacturing.
  • Acknowledged significant impact of mechanochemical synthesis in academia and industry.
  • Outlined challenges in scaling and adopting efficient solvent-free methods.
  • Identified opportunities for innovation in continuous chemical manufacturing.

Cite This Study

Crawford et al. (2026) studied this question.

synapsesocial.com/papers/69fada7f03f892aec9b1e4d0https://doi.org/10.1039/d6sc90085b
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