March 3, 2026Current Medicinal Chemistry0 citations
An Immune Cell Activation Signature for Non - Small Cell Lung Cancer Revealed Tumor Microenvironment Heterogeneity and the Role of RORA in Regulating ZNF490/NDUFA12 Axis
Effective model captures the heterogeneity of non-small cell lung cancer (NSCLC) tumors, showing varied immune responses.
RORA promotes ZNF490 expression, which in turn inhibits nuclear dehydrogenases and lowers oxidative phosphorylation processes.
Understanding the RORA-ZNF490/NDUFA12 axis could lead to new therapeutic approaches in NSCLC management.
Highlights the necessity to explore tumor microenvironment's role in shaping immune cell activity and cancer progression.
Abstract
The model is robust and effectively reflects NSCLC heterogeneity while predicting prognosis. RORA promotes the expression of ZNF490 to inhibit NUDFs and oxidative phosphorylation.