Low baseline LDL-C is a significant predictor of both transplant-associated thrombotic microangiopathy and overall survival in HSCT recipients, indicating its clinical relevance.
Patients with baseline LDL-C <72 mg/dL exhibited a 50% incidence of TA-TMA, markedly higher than the 24% in those with LDL-C ≥72 mg/dL (p=0.01).
Lipid profiles showed fluctuations post-transplant, with significant increases in LDL-C and oxLDL, and notable decreases in HDL-C and triglycerides, highlighting metabolic changes.
Dynamic analysis indicated correlations between changes in LDL-C and oxLDL, supporting the need for further research on lipids as risk factors for HSCT outcomes.