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March 15, 2026The American Surgeon1 citations

Safety and Efficacy of Ketorolac in the Management of Pain for Postoperative Pediatric General Surgery Patients

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ZFZoe FlyerAGAndreina GironRJRebecca John

Key Points

  • Evaluate the safety and efficacy of Ketorolac for pain management in postoperative pediatric general surgery patients.
  • Retrospective cohort study from a single institution
  • Included children ages 0-18 who underwent various surgeries
  • Analyzed demographics and pain outcomes using statistical methods
  • 5455 patients identified with variations in ketorolac administration
  • Patients receiving ketorolac reported higher pain scores post-surgery
  • Ketorolac use associated with 40% reduced odds of opioid use after surgery
  • Lower incidence of blood transfusions in ketorolac recipients

Abstract

PurposeKetorolac is commonly cautioned with a possible effect of bleeding. The safety and efficacy of Ketorolac has not been examined in children who have undergone general surgery procedures.MethodsA single institution retrospective cohort study examining children ages 0-18 from 2017-2022 with and without Ketorolac P P P 5) after surgery (40% vs 23%, P P P P = 0.005).ConclusionKetorolac does not increase the risk of bleeding requiring transfusion and decreases opioid administration. Ketorolac is efficacious in this patient population either alone or in combination with opioids and improves pain control compared to opioids alone.

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Cite This Study

Flyer et al. (2026) studied this question.

synapsesocial.com/papers/69b606ea83145bc643d1d760https://doi.org/10.1177/00031348261419764
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