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April 10, 2026Clinical and Translational Radiation Oncology0 citationsOpen Access

Plasma serine and glycine in relation to clinical outcomes following neoadjuvant radiotherapy for rectal cancer

NZNienke R.K. ZwartPUPer Magne UelandAMAdrian McCann

Key Points

  • To explore the relationship between the plasma serine/glycine ratio and clinical outcomes following neoadjuvant radiotherapy for rectal cancer.
  • Measured plasma serine and glycine levels in rectal cancer patients
  • Analyzed the serine/glycine ratio in relation to clinical outcomes
  • Investigated the role of SHMT enzyme activity
  • Found a potential association between serine/glycine ratio and rectal cancer recurrence
  • Indicated a need for further studies to confirm these findings
  • Suggested exploring strategies to target SHMT activity in cancer treatment

Abstract

Conclusion:This is the first study demonstrating a potential association between the serine/glycine ratio, an indicator of SHMT enzyme activity, and rectal cancer recurrence.Further studies are warranted to confirm these findings, as well as investigate underlying biological mechanisms and potentially explore strategies to target SHMT enzyme activity in the context of cancer treatment.

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Cite This Study

Zwart et al. (2026) studied this question.

synapsesocial.com/papers/69d892886c1944d70ce03e93https://doi.org/10.1016/j.ctro.2026.101159
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  5. 5CMS subtypes correlate with complete response in trial of neoadjuvant Galunisertib plus chemoradiation in rectal cancer2026