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April 10, 2026Journal of Medical Case Reports0 citationsOpen Access

Pseudoepitheliomatous hyperplasia of the prepuce, a benign mimic of penile squamous cell carcinoma: a case report

STSenthil Kumar ThiagarajanBSBalaji SubramaniamRRR. S. Rohitha

Key Points

  • This report aims to emphasize the need to include pseudoepitheliomatous hyperplasia in the diagnosis of suspicious penile lesions.
  • Case report of an elderly patient with suspicious penile lesion.
  • Histopathological examination and biopsy performed for confirmation.
  • Differential diagnosis assessed to rule out penile squamous cell carcinoma.
  • Histopathological findings confirmed pseudoepitheliomatous hyperplasia.
  • Avoided unnecessary radical surgeries like penectomy.
  • Emphasized the significance of early recognition for optimal patient outcomes.

Abstract

This case highlights the importance of including PEH in the differential diagnosis of suspicious penile lesions, particularly in elderly patients. Histopathological confirmation through biopsy is crucial to avoid unnecessary radical surgeries, such as partial or total penectomy. Early recognition and appropriate management can preserve function while ensuring optimal patient outcomes.

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Cite This Study

Thiagarajan et al. (2026) studied this question.

synapsesocial.com/papers/69d893eb6c1944d70ce04e36https://doi.org/10.1186/s13256-026-05999-9
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