The aim is to explore the architecture of glial pathology in the human olfactory system in relation to Alzheimer's disease.
Analyzed post mortem human brain samples from Alzheimer's disease patients.
Examined spatial patterns of glial pathology in the olfactory system.
Compared findings to other brain regions to assess regional vulnerabilities.
Identified diverse and spatially uneven glial pathology architectures in the olfactory system.
Highlight that the olfactory system shows early signs of vulnerability in Alzheimer's disease.
Demonstrated that the olfactory system may be affected before other brain regions.
Abstract
Findings demonstrate spatially heterogenous glial pathology architectures in the human olfactory system, supporting its role as an early and regionally diverse site of AD vulnerability.