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April 10, 2026ACS Nano

Tumor-Selective Autophagy Blockade of Renal-Clearable Bi 2 S 3 Nanoflowers for Precise Photothermal Therapy

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Authors

FGFene GaoXLXin LiRZRuirui Zhang

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Overview

Demonstrates enhanced tumor targeting and effective cancer treatment using Bi2S3 nanoflowers, indicating a new approach to minimize side effects.

Key Points

  • The study aims to develop a cancer treatment strategy that minimizes off-target effects while maximizing tumor selectivity.
  • Engineered Bi2S3 nanoflowers with MMP2-responsive peptide for targeted delivery.
  • Analyzed accumulation of nanoflowers in tumor tissue versus normal tissues.
  • Evaluated the effects of photothermal ablation combined with autophagy inhibition.
  • Performed real-time visualization of nanoparticle biodistribution using CT.
  • Tumor-selective autophagy blockade led to enhanced aggregation of Bi2S3 nanoflowers.
  • Micron-scale structures disrupted lysosomal membranes in tumor cells.
  • Achieved complete tumor eradication in murine breast cancer models.
  • Demonstrated rapid renal clearance of particles to reduce normal tissue exposure.

Cite This Study

Gao et al. (2026) studied this question.

synapsesocial.com/papers/69d894ec6c1944d70ce05e96https://doi.org/10.1021/acsnano.6c00474
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