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April 10, 2026Clinical Proteomics0 citationsOpen Access

Enhancing Personalized COVID-19 Treatment Through Computational Proteomics

Computational proteomics to enhance personalized treatment of COVID-19 and Long COVID

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Authors

DSDebasis SahuLNLogan R. Van NynattenDTDavid Tweddell

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Overview

Computational proteomics identifies biomarkers and therapeutic targets in COVID-19 and Long COVID, suggesting novel treatment strategies.

Key Points

  • The research aims to improve personalized treatment strategies for COVID-19 and Long COVID by utilizing proteomics to understand molecular changes.
  • Used targeted and untargeted proteomic analyses to investigate plasma samples.
  • Performed cellular deconvolution to assess tissue-specific contributions.
  • Applied bioinformatics and machine learning for biomarker discovery and drug repurposing.
  • Identified disease-relevant pathways that contribute to acute and long-term symptoms.
  • Pinpointed therapeutic targets for both the acute infection phase and Long COVID.
  • Provided insights that facilitate the development of personalized treatment strategies.
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Cite This Study

Sahu et al. (2026) studied this question.

synapsesocial.com/papers/69d895486c1944d70ce0635ehttps://doi.org/10.1186/s12014-026-09601-8
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Plasma Proteomics Elucidated a Protein Signature in COVID-19 Patients with Comorbidities and Early-Diagnosis Biomarkers2024 · 3 citations
  2. 2Longitudinal plasma proteomic analysis of 1117 hospitalized patients with COVID-19 identifies features associated with severity and outcomes2024 · 13 citations
  3. 3Distinguishing post-COVID from long-COVID in adults: Development and validation of a biomarker signature using targeted proteomics and machine learning in a cross-sectional observational study2026 · 1 citations
  4. 4A reduced proteomic signature in critically ill Covid-19 patients determined with plasma antibody micro-array and machine learning2024 · 2 citations
  5. 5Alterations in plasma proteome during acute COVID-19 and recovery2024