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April 10, 2026Nature Communications0 citationsOpen Access

DNA Methylation Establishment in Primate Germ Cell Development

Establishment of DNA methylation during primate germ cell development

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Authors

KKKazuaki KojimaYLYi LiSTShin-ichi Tomizawa

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Overview

Demonstrates de novo DNA methylation in primate germ cells, highlighting developmental differences in males and females.

Key Points

  • To investigate the establishment of DNA methylation during germ cell development in primates.
  • Analyzed DNA methylation patterns in primordial germ cells of marmosets, macaques, and humans.
  • Used single-cell bisulfite sequencing to examine spermatogonia across species.
  • Compared DNA methylation processes in male prospertmatogonia and female growing oocytes.
  • De novo methylation occurs postnatally in prospermatogonia and growing oocytes.
  • Methylation in monkey prospermatogonia is a prolonged process, spanning 6 months to 1 year.
  • Genic regions acquire DNA methylation faster than intergenic regions.
  • Mitotic divisions occur during methylation establishment in prospermatogonia, differing from mice.

Cite This Study

Kojima et al. (2026) studied this question.

synapsesocial.com/papers/69d8955f6c1944d70ce065cahttps://doi.org/10.1038/s41467-026-71405-z
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