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April 10, 2026Acta Biochimica et Biophysica SinicaOpen Access

Presenilin 1 is located at mitochondrial inner membrane and regulates mitochondrial crista junction protein arrangement and crista formation in HEK293 cells

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Authors

PYPan YouPZPengjin ZhuHYHui Yu

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Overview

Knockout cell lines reveal that PS1 affects mitochondrial structure and function, highlighting its role in Alzheimer's disease.

Key Points

  • This research aims to understand the role of presenilin 1 (PS1) in mitochondrial function and structure, particularly its localization and interactions.
  • Generated PS1 knockout cell lines
  • Investigated mitochondrial structure and function
  • Analyzed ATP production, membrane potential, and protein interactions
  • Examined effects on mitochondrial crista structure
  • PS1 is localized to the mitochondrial inner membrane
  • PS1 deficiency reduces ATP production and impairs mitochondrial respiration
  • Loss of PS1 leads to abnormal mitochondrial crista structure
  • PS1 absence disrupts calcium homeostasis and increases reactive oxygen species levels

Cite This Study

You et al. (2026) studied this question.

synapsesocial.com/papers/69d895be6c1944d70ce06cd1https://doi.org/10.3724/abbs.2026064
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Also Consider

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  4. 4Cell growth and mitochondrial anomalies in induced pluripotent stem cells with Presenilin 1 mutation2024
  5. 5Microtubular interactions of presenilin direct kinesis of Aβ peptide and its precursors2003 · 18 citations