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April 10, 2026European Journal of Neurology0 citationsOpen Access

Gene–Environment Interactions for Alzheimer's Disease Pathology in Cognitively Normal Adults: The CABLE Study

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ZGZe‐Xin GuoXHXiaoyu HeYGYi‐Jun Ge

Key Points

  • This research aims to explore how genetic and environmental factors interact to influence Alzheimer's disease pathology in cognitively normal adults.
  • Analyzed associations between genetic risk (AD-PRS) and amyloidosis severity.
  • Examined the impact of modified risk factors such as anemia, gingivitis, and anxiety on biomarker ratios.
  • Investigated the relationship between healthy lifestyle choices and amyloid burden across different genetic risk groups.
  • AD-PRS showed a significant correlation with the severity of amyloidosis.
  • Modified risk factors affected biomarker ratios differently based on genetic risk levels.
  • Individuals with high genetic risk who maintained a healthy lifestyle exhibited a reduced amyloid burden.

Abstract

AD-PRS was associated with amyloidosis severity. The associations between modified risk factors (anemia, gingivitis, and anxiety) and biomarker ratios differed by genetic risk strata. Moreover, a healthy lifestyle was associated with less amyloid burden in individuals with high genetic risk. These findings can be used to generate hypotheses for future longitudinal studies to investigate whether targeted management of these factors influences AD pathological progression.

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Cite This Study

Guo et al. (2026) studied this question.

synapsesocial.com/papers/69d896166c1944d70ce074b8https://doi.org/10.1111/ene.70558
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