Dual-action depot formulation of hyaluronic acid/poloxamer in-situ gel enclosing lavender oil-based syringic acid nanoemulsion for enhanced intra-articular treatment of osteoarthritis
The research aims to evaluate a new formulation combining hyaluronic acid and lavender oil for treating osteoarthritis.
Developed a dual-action depot formulation using HA, poloxamer, and lavender oil.
Enclosed syringic acid nanoemulsion within the in-situ gel.
Assessed therapeutic efficacy for intra-articular applications.
The nanoemulsion displayed enhanced sustained therapeutic effects.
Indicated potential for improved intra-articular delivery and treatment of osteoarthritis.
Abstract
This study highlights the potential of the nanoemulsion in a HA/P407/P188 in-situ gel as a promising strategy for intra-articular OA therapy, with an enhanced sustained therapeutic efficacy.