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April 10, 2026Nature CommunicationsOpen Access

CB1 receptor signaling at the cingulate-striatal circuit is anxiogenic

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Authors

TKThomas J. KellyXLXiaojie LiuYHYao Huang

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Overview

Research demonstrates how CB1 receptor activity influences anxiety in mice via specific neural circuits, suggesting targeted interventions.

Key Points

  • This research aims to elucidate the neural mechanisms by which CB1 receptor signaling contributes to anxiety induced by cannabinoids.
  • Used optogenetics to manipulate the ACC → DMS circuit in mice.
  • Assessed anxiety-like behaviors and aversion to THC after CB1 receptor deletion.
  • Monitored excitatory transmission changes and eCB release using in vivo fiber photometry.
  • Found that cannabinoid signaling suppresses excitatory transmission in the ACC → DMS circuit.
  • Demonstrated that deletion of CB1 receptors reduced anxiety-like behaviors in mice.
  • Showed that aversive stimuli increased eCB release from the DMS, activating CB1 receptors in the ACC.

Cite This Study

Kelly et al. (2026) studied this question.

synapsesocial.com/papers/69d896566c1944d70ce07a2bhttps://doi.org/10.1038/s41467-026-71574-x
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice1999 · 1,070 citations
  2. 2A connectional hub in the rostral anterior cingulate cortex links areas of emotion and cognitive control2019 · 129 citations