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April 10, 20260 citationsOpen Access

Evolution and Complexity of Tumor Necrosis Factor Superfamily in Tunicates

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Authors

IMIgnacio Marín

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Overview

Demonstrates complex tnfsf gene evolution in tunicates, suggesting distinct pathways from vertebrates.

Key Points

  • The research aims to understand the complexity and evolution of the TNF superfamily in tunicates compared to vertebrates.
  • Analyzed 24 model tunicate species for TNFSF gene presence and arrangement.
  • Compared tunicate TNFSF genes with those of vertebrates to identify evolutionary patterns.
  • Utilized transcription data from Ciona intestinalis to assess gene expression during development.
  • Tunicates exhibit a more complex TNFSF gene landscape than many vertebrates, with some species having up to 14 genes.
  • A common ancestor likely had four TNFSF genes; three underwent independent duplications in early tunicate evolution.
  • Gene expression data indicate multiple developmental roles for TNFSF genes, linked to immunity.

Cite This Study

Ignacio Marín (2026) studied this question.

synapsesocial.com/papers/69d896566c1944d70ce07beahttps://doi.org/10.1371/journal.pone.0338039.s001
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