Pathway-specific polygenic risk scores were differentially associated with cardiorenal outcomes and related circulating proteins in multi-ethnic Asians with type 2 diabetes.
Are pathway-specific polygenic risk scores associated with cardiorenal complications in Asians with Type 2 diabetes?
Pathway-specific polygenic risk scores show differential associations with cardiorenal outcomes in Asian patients with type 2 diabetes, highlighting the potential relevance of biologically informed genetic pathways.
In a multi-ethnic Asian population, pathway-specific genetic susceptibility was differentially associated with cardiorenal outcomes and related circulating proteins. These findings suggest the potential relevance of biologically informed genetic pathways in diverse populations and warrant validation in independent cohorts.
Gurung et al. (2026) studied this question. Pathway-specific polygenic risk scores were differentially associated with cardiorenal outcomes and related circulating proteins in multi-ethnic Asians with type 2 diabetes.