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April 10, 2026Diabetes Therapy0 citationsOpen Access

Real-World Effectiveness and Safety of Escalating Once-Weekly Semaglutide from 0.5 to 1.0 mg in Type 2 Diabetes

GSGenki SatoHUHiroshi UchinoKTKota Takuma

Key Points

  • The study aims to evaluate the real-world effectiveness and safety of increasing the semaglutide dose in individuals with type 2 diabetes.
  • Conducted a retrospective analysis of clinical data from UMIN-CTR.
  • Evaluated responses to escalating doses of semaglutide from 0.5 mg to 1.0 mg.
  • Assessed both effectiveness and safety outcomes associated with dosage changes.
  • Found improvements in glycemic control with the higher dose of semaglutide.
  • Reported a satisfactory safety profile for patients during dosage escalation.

Abstract

UMIN Clinical Trials Registry (UMIN-CTR), UMIN000059813, retrospectively registered on November 18, 2025.

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Cite This Study

Sato et al. (2026) studied this question.

synapsesocial.com/papers/69d8967d6c1944d70ce07faehttps://doi.org/10.1007/s13300-026-01864-6
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